MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1.

@article{Sachdeva2010MicroRNA145SC,
  title={MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1.},
  author={Mohit Sachdeva and Young Woong Mo},
  journal={Cancer research},
  year={2010},
  volume={70 1},
  pages={
          378-87
        }
}
MicroRNAs are important gene regulators that could play a profound role in tumorigenesis. Our previous studies indicate that miR-145 is a tumor suppressor capable of inhibiting tumor cell growth both in vitro and in vivo. In this study, we show that miR-145 exerts its function in a cell-specific manner. Although miR-145 inhibits cell growth in MCF-7 and HCT-116 cells, it has no significant effect on cell growth in metastatic breast cancer cell lines. However, miR-145 significantly suppresses… CONTINUE READING

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