MicroRNA-145 repairs infarcted myocardium by accelerating cardiomyocyte autophagy.

  title={MicroRNA-145 repairs infarcted myocardium by accelerating cardiomyocyte autophagy.},
  author={Kenshi Higashi and Yoshihisa Yamada and Shinya Minatoguchi and Shinya Baba and Masamitsu Iwasa and Hiromitsu Kanamori and Masanori Kawasaki and Kazuhiko Nishigaki and Genzou Takemura and Minami Kumazaki and Yukihiro Akao},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={309 11},
We investigated whether microRNA-145 (miR-145) has a cardioprotective effect in a rabbit model of myocardial infarction (MI) and in H9c2 rat cardiomyoblasts. Rabbits underwent 30 min of coronary occlusion, followed by 2 days or 2 wk of reperfusion. Control microRNA (control group; 2.5 nmol/kg, n = 10) or miR-145 (miR-145 group, 2.5 nmol/kg, n = 10) encapsulated in liposomes was intravenously administered immediately after the start of reperfusion. H9c2 rat cardiomyoblasts were transfected with… CONTINUE READING
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