MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor.

@article{Vallim2013MicroRNA144RH,
  title={MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor.},
  author={Thomas Quad de Aguiar Vallim and Elizabeth J Tarling and Tammy D. Kim and Mete Civelek and {\'A}ngel Bald{\'a}n and Christine Esau and Peter A. Edwards},
  journal={Circulation research},
  year={2013},
  volume={112 12},
  pages={1602-12}
}
RATIONALE The bile acid receptor farnesoid X receptor (FXR) regulates many aspects of lipid metabolism by variouscomplex and incompletely understood molecular mechanisms. We set out to investigate the molecular mechanisms for FXR-dependent regulation of lipid and lipoprotein metabolism. OBJECTIVE To identify FXR-regulated microRNAs that were subsequently involved in regulating lipid metabolism. METHODS AND RESULTS ATP binding cassette transporter A1 (ABCA1) is a major determinant of plasma… CONTINUE READING
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