MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer

  title={MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer},
  author={Enders K. O. Ng and Wing Pui Tsang and Samuel S. M Ng and Huanyu Jin and Jeffrey Xu Yu and J J Li and Christoph R{\"o}cken and Matthias P. A. Ebert and Tracy Kwok and Joseph J. Y. Sung},
  journal={British Journal of Cancer},
  pages={699 - 706}
Background:MicroRNAs (miRNAs) are 19-25-nucleotides regulatory non-protein-coding RNA molecules that regulate the expressions of a wide variety of genes, including some involved in cancer development. In this study, we investigated the possible role of miR-143 in colorectal cancer (CRC).Methods:Expression levels of human mature miRNAs were examined using real-time PCR-based expression arrays on paired colorectal carcinomas and adjacent non-cancerous colonic tissues. The downregulation of miR… CONTINUE READING
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