MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1α.

@article{Yeh2013MicroRNA138SO,
  title={MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1α.},
  author={Yu-Ming Yeh and Chi-Mu Chuang and K. W. Chao and L Wang},
  journal={International journal of cancer},
  year={2013},
  volume={133 4},
  pages={867-78}
}
Metastasis is the major factor affecting patient survival in ovarian cancer. However, its molecular mechanisms remain unclear. Our study used isogenic pairs of low- and high-invasive ovarian cancer cell lines to demonstrate the downregulation of miRNA-138 in the highly invasive cells, and its functioning as an inhibitor of cell migration and invasion. An orthotopic xenograft mouse model further demonstrated that the expression of miRNA-138 inhibited ovarian cancer metastasis to other organs… CONTINUE READING
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