MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts.

@article{Matkovich2010MicroRNA133aPA,
  title={MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts.},
  author={Scot J Matkovich and Wei Wang and Yizheng Tu and William H. Eschenbacher and Lisa E Dorn and Gianluigi Condorelli and Abhinav Diwan and Jeanne M Nerbonne and Gerald W. Dorn},
  journal={Circulation research},
  year={2010},
  volume={106 1},
  pages={166-75}
}
RATIONALE MicroRNA (miR)-133a regulates cardiac and skeletal muscle differentiation and plays an important role in cardiac development. Because miR-133a levels decrease during reactive cardiac hypertrophy, some have considered that restoring miR-133a levels could suppress hypertrophic remodeling. OBJECTIVE To prevent the "normal" downregulation of miR-133a induced by an acute hypertrophic stimulus in the adult heart. METHODS AND RESULTS miR-133a is downregulated in transverse aortic… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 169 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Changes in regulatory microRNA expression in myocardium of heart failure patients on left ventricular assist device support.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation • 2008

Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis.

Proceedings of the National Academy of Sciences of the United States of America • 2008

Similar Papers

Loading similar papers…