MicroRNA-133a, downregulated in osteosarcoma, suppresses proliferation and promotes apoptosis by targeting Bcl-xL and Mcl-1.

@article{Ji2013MicroRNA133aDI,
  title={MicroRNA-133a, downregulated in osteosarcoma, suppresses proliferation and promotes apoptosis by targeting Bcl-xL and Mcl-1.},
  author={Fang Ji and H. Zhang and Y. Wang and Ming Li and Weidong Xu and Yifan Kang and Zhiwei Wang and Zi-min Wang and P. Cheng and D. Tong and Cheng Li and Hao Tang},
  journal={Bone},
  year={2013},
  volume={56 1},
  pages={
          220-6
        }
}
Deregulated microRNAs and their roles in cancer development have attracted much attention. Although miR-133a has been shown to be important in osteogenesis, its roles in osteosarcoma carcinogenesis and progression remain unknown. Hence, we focused on the expression and mechanisms of miR-133a in osteosarcoma development in this study. We found that miR-133a was downregulated in osteosarcoma cell lines and primary human osteosarcoma tissues, and its decrease was significantly correlated with… Expand
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