MicroRNA-133 controls cardiac hypertrophy

  title={MicroRNA-133 controls cardiac hypertrophy},
  author={A. Car{\`e} and D. Catalucci and F. Felicetti and D. Bonci and A. Addario and P. Gallo and Marie-Louise Bang and P. Segnalini and Y. Gu and N. Dalton and L. Elia and M. Latronico and M. H{\o}ydal and C. Autore and M. A. Russo and G. Dorn and {\O}. Ellingsen and P. Ruiz-Lozano and K. Peterson and C. Croce and C. Peschle and G. Condorelli},
  journal={Nature Medicine},
  • A. Carè, D. Catalucci, +19 authors G. Condorelli
  • Published 2007
  • Medicine
  • Nature Medicine
  • Growing evidence indicates that microRNAs (miRNAs or miRs) are involved in basic cell functions and oncogenesis. Here we report that miR-133 has a critical role in determining cardiomyocyte hypertrophy. We observed decreased expression of both miR-133 and miR-1, which belong to the same transcriptional unit, in mouse and human models of cardiac hypertrophy. In vitro overexpression of miR-133 or miR-1 inhibited cardiac hypertrophy. In contrast, suppression of miR-133 by 'decoy' sequences induced… CONTINUE READING
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