MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1.

@article{Strum2009MicroRNA1R,
  title={MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1.},
  author={Jay C. Strum and Jennifer H. Johnson and James W. Ward and Hongbo Xie and John A. Feild and Austin Hester and Alexander Alford and Katrina M. Waters},
  journal={Molecular endocrinology},
  year={2009},
  volume={23 11},
  pages={
          1876-84
        }
}
Human adipose tissue secretes a number of proinflammatory mediators that may contribute to the pathophysiology of obesity-related disorders. Understanding the regulatory pathways that control their production is paramount to developing effective therapeutics to treat these diseases. Using primary human adipose-derived stem cells as a source of preadipocytes and in vitro differentiated adipocytes, we found IL-8 and monocyte chemoattractant protein-1 (MCP-1) are constitutively secreted by both… CONTINUE READING

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