MicroRNA-1290 promotes asiatic acid‑induced apoptosis by decreasing BCL2 protein level in A549 non‑small cell lung carcinoma cells.

@article{Kim2014MicroRNA1290PA,
  title={MicroRNA-1290 promotes asiatic acid‑induced apoptosis by decreasing BCL2 protein level in A549 non‑small cell lung carcinoma cells.},
  author={Ki Bbeum Kim and Karam Kim and Seunghee Bae and Yeonghmin Choi and Hwa Jun Cha and Soo Yeon Kim and Jae Ho Lee and So Hyeon Jeon and Ho Jung Jung and Kyu Joong Ahn and In-sook An and Sungkwan An},
  journal={Oncology reports},
  year={2014},
  volume={32 3},
  pages={1029-36}
}
Asiatic acid, a triterpenoid derived from Centella asiatica, is a putative anticancer agent in several types of cancer cells. Investigations of its biological role in negative regulation of cell growth have focused on the extent of induction of apoptosis in a cell-type-specific manner. In this study, we identified an important regulator of asiatic acid-induced cell death, microRNA (miR)-1290, which sensitizes cells to asiatic acid-induced cytotoxicity and negatively regulates BCL2 expression… CONTINUE READING

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