MicroRNA-1285 inhibits the expression of p53 by directly targeting its 3' untranslated region.

Abstract

The well-known tumor suppressor p53 plays critical roles in the modulation of multiple cellular processes. The regulation of p53 is complicated and remains elusive. In this study, we used a high-throughput luciferase reporter screen to demonstrate that p53 can be regulated by microRNA-1285 (miR-1285). Notably, miR-612, which has the same seed sequence as… (More)
DOI: 10.1016/j.bbrc.2010.04.112

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