MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia.

  title={MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia.},
  author={Evelien Mets and Gert Van Peer and J. C. van der Meulen and Michael H. Boice and Tom Taghon and Steven Goossens and Pieter Mestdagh and Yves Benoit and Barbara de Moerloose and Nadine van Roy and Bruce Poppe and Jo Vandesompele and Hans-Guido Wendel and Pieter Van Vlierberghe and Frank Speleman and Pieter Rondou},
  volume={99 8},
T-cell acute lymphoblastic leukemia arises from the leukemic transformation of developing thymocytes and results from cooperative genetic lesions. Inactivation of the PHF6 gene is frequently observed in T-cell acute lymphoblastic leukemia, suggesting an important tumor suppressive role for PHF6 in the pathobiology of this leukemia. Although the precise function of PHF6 is still unknown, this gene is most likely involved in chromatin regulation, a strongly emerging theme in T-cell acute… CONTINUE READING
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