MicroRNA-126 modulates endothelial SDF-1 expression and mobilization of Sca-1(+)/Lin(-) progenitor cells in ischaemia.

@article{Solingen2011MicroRNA126ME,
  title={MicroRNA-126 modulates endothelial SDF-1 expression and mobilization of Sca-1(+)/Lin(-) progenitor cells in ischaemia.},
  author={Coen van Solingen and Hetty C. de Boer and Roel Bijkerk and Matthieu Monge and Annemarie M. van Oeveren-Rietdijk and Leonard Seghers and Amanda Pronk and Eric P. van der Veer and Paul H. A. Quax and Ton J Rabelink and Anton Jan van Zonneveld},
  journal={Cardiovascular research},
  year={2011},
  volume={92 3},
  pages={449-55}
}
AIMS MicroRNA-126 (miR-126), which is enriched in endothelial cells, plays a role in angiogenesis. Based on the seed sequence, miR-126 can also be predicted to regulate vasculogenesis by modulating the endothelial expression of stromal cell-derived factor-1 (SDF-1). METHODS AND RESULTS Using miR-reporter constructs, we first validated that miR-126 inhibits SDF-1 expression in endothelial cells in vitro. Next, we investigated the potential relevance of this observation with respect to the… CONTINUE READING