MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1

@article{Schober2014MicroRNA1265pPE,
  title={MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1},
  author={Andreas Schober and Maliheh Nazari-Jahantigh and Yuanyuan Wei and Kiril Bidzhekov and Felix Gremse and Jochen Grommes and Remco T. A. Megens and Kathrin Heyll and Heidi Noels and Michael Hristov and Shusheng Wang and Fabian Kiessling and Eric N. Olson and Christian Weber},
  journal={Nature Medicine},
  year={2014},
  volume={20},
  pages={368-376}
}
  • Andreas Schober, Maliheh Nazari-Jahantigh, +11 authors Christian Weber
  • Published 2014
  • Biology, Medicine
  • Nature Medicine
  • Atherosclerosis, a hyperlipidemia-induced chronic inflammatory process of the arterial wall, develops preferentially at sites where disturbed laminar flow compromises endothelial cell (EC) function. Here we show that endothelial miR-126-5p maintains a proliferative reserve in ECs through suppression of the Notch1 inhibitor delta-like 1 homolog (Dlk1) and thereby prevents atherosclerotic lesion formation. Endothelial recovery after denudation was impaired in Mir126−/− mice because lack of miR… CONTINUE READING

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