MicroRNA-125b-2 overexpression represses ectodermal differentiation of mouse embryonic stem cells

@inproceedings{Deng2015MicroRNA125b2OR,
  title={MicroRNA-125b-2 overexpression represses ectodermal differentiation of mouse embryonic stem cells},
  author={Shanshan Deng and Yanli Zhang and Chundi Xu and Duan Yang Ma},
  booktitle={International journal of molecular medicine},
  year={2015}
}
microRNAs (miRNAs or miRS) have been demonstrated to be essential for neural development. miR-125b-2, presented on human chromosome 21, is overexpressed in neurons of individuals with Down syndrome (DS) with cognitive impairments. It has been reported that miR-125b-2 promotes specific types of neuronal differentiation; however, the function of miR-125b-2 in the early development of the embryo has remained to be fully elucidated. In the present study, a mouse embryonic stem cell (mESC) line was… CONTINUE READING

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