MicroRNA-125b-2 overexpression represses ectodermal differentiation of mouse embryonic stem cells

Abstract

microRNAs (miRNAs or miRS) have been demonstrated to be essential for neural development. miR-125b-2, presented on human chromosome 21, is overexpressed in neurons of individuals with Down syndrome (DS) with cognitive impairments. It has been reported that miR-125b-2 promotes specific types of neuronal differentiation; however, the function of miR-125b-2 in… (More)
DOI: 10.3892/ijmm.2015.2238

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