MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis.

@article{Koukos2013MicroRNA124RS,
  title={MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis.},
  author={Georgios Koukos and Christos Polytarchou and Jess L. Kaplan and Alessio Morley-Fletcher and Beatriz Gras-Miralles and Efi G Kokkotou and Mariah Baril-Dore and Charalabos Pothoulakis and Harland S. Winter and Dimitrios C. Iliopoulos},
  journal={Gastroenterology},
  year={2013},
  volume={145 4},
  pages={842-52.e2}
}
BACKGROUND & AIMS Altered levels and functions of microRNAs (miRs) have been associated with inflammatory bowel diseases (IBDs), although little is known about their roles in pediatric IBD. We investigated whether colonic mucosal miRs are altered in children with ulcerative colitis (UC). METHODS We used a library of 316 miRs to identify those that regulate phosphorylation of signal transducer and activator of transcription 3 (STAT3) in NCM460 human colonocytes incubated with interleukin-6… CONTINUE READING
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