MicroRNA-10b targets E-cadherin and modulates breast cancer metastasis

  title={MicroRNA-10b targets E-cadherin and modulates breast cancer metastasis},
  author={Yong Liu and Jing Zhao and P. Zhang and Y. Zhang and Sanyuan Sun and S. Yu and Qing-song Xi},
  journal={Medical Science Monitor : International Medical Journal of Experimental and Clinical Research},
  pages={BR299 - BR308}
  • Yong Liu, Jing Zhao, +4 authors Qing-song Xi
  • Published 2012
  • Medicine
  • Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
  • Summary Background Recent studies have suggested that microRNA-10b (miR-10b) acts as a promoter of metastasis in breast cancer, although the underlying mechanism remains largely unknown. In this study, we provide the first evidence that E-cadherin (E-cad) is a potential target of miR-10b. Material/Method By applying gain-of-function and loss-of-function approaches in the metastatic breast cancer cell line MDA-MB-231, we demonstrated that miR-10b is necessary and sufficient to regulate the… CONTINUE READING
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