MicroRNA-10b targets E-cadherin and modulates breast cancer metastasis

  title={MicroRNA-10b targets E-cadherin and modulates breast cancer metastasis},
  author={Yong Liu and Jing Zhao and Pei-ying Zhang and Runsheng Huang and San-Yuan Sun and Shiying Yu and Qing-song Xi},
  booktitle={Medical science monitor : international medical journal of experimental and clinical research},
BACKGROUND Recent studies have suggested that microRNA-10b (miR-10b) acts as a promoter of metastasis in breast cancer, although the underlying mechanism remains largely unknown. In this study, we provide the first evidence that E-cadherin (E-cad) is a potential target of miR-10b. MATERIAL/METHOD By applying gain-of-function and loss-of-function approaches in the metastatic breast cancer cell line MDA-MB-231, we demonstrated that miR-10b is necessary and sufficient to regulate the cellular… CONTINUE READING


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Raman V: Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer

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