MicroRNA-10b regulates tumorigenesis in neurofibromatosis type 1.

  title={MicroRNA-10b regulates tumorigenesis in neurofibromatosis type 1.},
  author={Guolin Chai and Ning Liu and Junrong Ma and Hua Li and Janet L. Oblinger and Agasanur K Prahalad and Meng Gong and L S Chang and Margaret Wallace and David Muir and Abhijit Guha and Roger J. Phipps and Janet M. Hock and Xijie Yu},
  journal={Cancer science},
  volume={101 9},
MicroRNAs (miRNAs) are frequently deregulated in human tumors, and play important roles in tumor development and progression. The pathological roles of miRNAs in neurofibromatosis type 1 (NF1) tumorigenesis are largely unknown. We demonstrated that miR-10b was up-regulated in primary Schwann cells isolated from NF1 neurofibromas and in cell lines and tumor tissues from malignant peripheral nerve sheath tumors (MPNSTs). Intriguingly, a significantly high level of miR-10b correlated with low… CONTINUE READING


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