MicroRNA-106b induces mitochondrial dysfunction and insulin resistance in C2C12 myotubes by targeting mitofusin-2.

@article{Zhang2013MicroRNA106bIM,
  title={MicroRNA-106b induces mitochondrial dysfunction and insulin resistance in C2C12 myotubes by targeting mitofusin-2.},
  author={Ying Zhang and Lei Yang and Yuan-fu Gao and Zhong-min Fan and Xiao-Yi Cai and Meng-yuan Liu and Xi-rong Guo and Chun-lin Gao and Zheng-kun Xia},
  journal={Molecular and cellular endocrinology},
  year={2013},
  volume={381 1-2},
  pages={230-40}
}
MicroRNA-106b (miR-106b) is reported to correlate closely with skeletal muscle insulin resistance and type 2 diabetes. The aim of this study was to identify an mRNA targeted by miR-106b which regulates skeletal muscle insulin sensitivity. MiR-106b was found to target the 3' untranslated region (3' UTR) of mitofusin-2 (Mfn2) through miR-106b binding sites and to downregulate Mfn2 protein abundance at the post-transcriptional level by luciferase activity assay combined with mutational analysis… CONTINUE READING