MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy

@inproceedings{Valera2017MicroRNA101MA,
  title={MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy},
  author={Elvira Valera and Brian Spencer and Jennifer Mott and Margarita Sol{\'i}s Trejo and A. Eneas Chavelas Adame and Michael Mante and Edward M. Rockenstein and Juan C Troncoso and Thomas Gerald Beach and Eliezer Masliah and Paula A. Desplats},
  booktitle={Front. Mol. Neurosci.},
  year={2017}
}
Synucleinopathies, neurodegenerative disorders with alpha-synuclein (α-syn) accumulation, are the second leading cause of neurodegeneration in the elderly, however no effective disease-modifying alternatives exist for these diseases. Multiple system atrophy (MSA) is a fatal synucleinopathy characterized by the accumulation of toxic aggregates of α-syn within oligodendroglial cells, leading to demyelination and neurodegeneration, and the reduction of this accumulation might halt the fast… CONTINUE READING
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