MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR/HIF-1α/VEGF signaling axis in breast cancer cells

@article{Pakravan2017MicroRNA100SB,
  title={MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR/HIF-1α/VEGF signaling axis in breast cancer cells},
  author={Katayoon Pakravan and Sadegh Babashah and Majid Sadeghizadeh and Seyed Javad Mowla and Majid Mossahebi-Mohammadi and Farangis Ataei and Nasim Dana and Mohammad Javan},
  journal={Cellular Oncology},
  year={2017},
  volume={40},
  pages={457-470}
}
BackgroundHuman mesenchymal stem cells (MSCs) have been shown to be involved in the formation and modulation of tumor stroma and in interacting with tumor cells, partly through their secretome. Exosomes are nano-sized intraluminal multi-vesicular bodies secreted by most types of cells and have been found to mediate intercellular communication through the transfer of genetic information via coding and non-coding RNAs to recipient cells. Since exosomes are considered as protective and enriched… CONTINUE READING

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