MicroRNA-100/99a, deregulated in acute lymphoblastic leukaemia, suppress proliferation and promote apoptosis by regulating the FKBP51 and IGF1R/mTOR signalling pathways

@article{Li2013MicroRNA10099aDI,
  title={MicroRNA-100/99a, deregulated in acute lymphoblastic leukaemia, suppress proliferation and promote apoptosis by regulating the FKBP51 and IGF1R/mTOR signalling pathways},
  author={X-J Li and X-Q Luo and B Han and Fang-ting Duan and Pan-Pan Wei and Y-Q Chen},
  journal={British Journal of Cancer},
  year={2013},
  volume={109},
  pages={2189 - 2198}
}
Background:MicroRNAs alter multiple cell processes and thus influence tumour carcinogenesis and progression. MiR-100 and miR-99a have been reported to be aberrantly expressed in acute leukaemia. In this study, we focused on their functions in acute lymphoblastic leukaemia (ALL) and the molecular networks in which they are involved.Methods:MiR-100 and miR-99a expression levels were measured in acute leukaemia patients by qRT–PCR. Kaplan−Meier analysis and log-rank tests were used to calculate… Expand
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References

SHOWING 1-10 OF 62 REFERENCES
Deregulation of miR-100, miR-99a and miR-199b in tissues and plasma coexists with increased expression of mTOR kinase in endometrioid endometrial carcinoma
TLDR
It is implicate that miRNA signatures can be considered promising biomarkers for early detection and prognosis of endometrioid endometrial carcinoma and miR-100 was an independent prognostic marker of overall survival. Expand
MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia
TLDR
A new pathway that miR-100 regulates G1/S transition and S-phase entry and blocks the terminal differentiation by targeting RBSP3, which partly in turn modulates the cell cycle effectors pRB/E2F1 in AML is revealed. Expand
Down-regulation of the microRNA-99 family members in head and neck squamous cell carcinoma.
TLDR
The deregulation of miR-99 family contributes to the tumorigenesis of HNSCC, in part by targeting IGF1R and mTOR signaling pathways. Expand
Upregulation of microRNA-100 predicts poor prognosis in patients with pediatric acute myeloid leukemia
TLDR
It is revealed that miR-100 upregulation was associated with poorer relapse-free and overall survival in pediatric AML patients, and may be used as an unfavorable prognostic marker iniatric AML. Expand
miR-99 family of MicroRNAs suppresses the expression of prostate-specific antigen and prostate cancer cell proliferation.
TLDR
It is determined that PSA is posttranscriptionally regulated by the miR-99 family members, at least partially, by repression of SMARCA5. Expand
Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia.
TLDR
The methylation and chromatin status of the miR-124a loci in ALL provided the grounds for new therapeutic strategies in ALL either targeting the epigenetic regulation of microRNAs and/or directly targeting the CDK6-Rb pathway. Expand
MiRNA Expression in Psoriatic Skin: Reciprocal Regulation of hsa-miR-99a and IGF-1R
TLDR
The differential expression of miRNAs in psoriatic involved and uninvolved skin as compared to normal skin is described, revealing an additional aspect of this complex disorder. Expand
Erg and AP-1 as determinants of glucocorticoid response in acute lymphoblastic leukemia
TLDR
It is found that activator protein 1 (AP-1), Ets related gene (Erg) and GR pathways were differentially regulated in sensitive and resistant ALL, which significantly advance the understanding of GC sensitivity and can be used to improve therapy of leukemia. Expand
Regulation of insulin-like growth factor-mammalian target of rapamycin signaling by microRNA in childhood adrenocortical tumors.
TLDR
Results reveal a novel mechanism of regulation of mTOR signaling by miRNAs, and they lay the groundwork for clinical evaluation of drugs inhibiting the mTOR pathway for treatment of adrenocortical cancer. Expand
MiR-125 in normal and malignant hematopoiesis
TLDR
A direct oncogenic role in the hematopoietic system has recently been demonstrated by several mouse models and targets of miR-125b include key proteins regulating apoptosis, innate immunity, inflammation and hematopolietic differentiation. Expand
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3
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5
...