MicroRNA-1 inhibits proliferation of hepatocarcinoma cells by targeting endothelin-1.

  title={MicroRNA-1 inhibits proliferation of hepatocarcinoma cells by targeting endothelin-1.},
  author={Dong Li and Pengyuan Y. Yang and Hua Li and Peng Cheng and Ling Zhang and Dong Wei and Xiaomei Su and Jingjing Peng and Hui Gao and Yong Hong Tan and Zhenguo Zhao and Yan Li and Zhongchun Qi and Yaocheng Rui and Tao Zhang},
  journal={Life sciences},
  volume={91 11-12},
AIMS MicroRNA-1 (miR-1) has been demonstrated as a tumor-suppressive miRNA, which shows a down-regulated pattern in several human malignancies including hepatocellular carcinoma (HCC). However, the pathophysiologic roles of miR-1 and their mechanisms in HCC tumorigenesis are still not totally elucidated. MAIN METHODS Pre-miR-1 was cloned into pSuper plasmid to overexpress the miR-1 in hepatoma cells. Real-time PCR and Western blot were applied to detect miR-1, ET-1 mRNA and protein levels… CONTINUE READING

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