MicroRNA‑mRNA integrated analysis based on a case of well‑differentiated thyroid cancer with both metastasis and metastatic recurrence.

@article{Zhang2018MicroRNAmRNAIA,
  title={MicroRNA‑mRNA integrated analysis based on a case of well‑differentiated thyroid cancer with both metastasis and metastatic recurrence.},
  author={Yunjie Zhang and Yushui Ma and Qing Xia and Fei Yu and Zhongwei Lv and Cheng-You Jia and Xiaopeng Jiang and Liang Zhang and Yunchao Shao and Wenting Xie and Gaixia Lu and Xia-Qing Yv and P-Y Zhong and Da Fu and Xiaofeng Wang},
  journal={Oncology reports},
  year={2018},
  volume={40 6},
  pages={
          3803-3811
        }
}
The incidence of well‑differentiated thyroid cancer (WDTC) is rapidly increasing. Poor survival follows distant metastasis (DM) and recurrence. In the present study, we aimed to analyze the expression alterations in different stages of WDTC and the regulatory mechanism of DM and the recurrence of DM. A male patient diagnosed with follicular thyroid cancer and distant metastasis in the eleventh thoracic vertebrae received total thyroidectomy and the removal of a metastatic lesion. A local… 

Figures from this paper

Profiling and Integrated Analysis of Differentially Expressed MicroRNAs as Novel Biomarkers of Hepatocellular Carcinoma
TLDR
This study revealed the general expression characteristics of specific differentially expressed miRNAs using a ceRNA network constructed from HCC samples and revealed the expression levels of Hsa-mir-1269a, hsa-miR-421 may be promising candidates.
microRNA-491-5p regulates osteogenic differentiation of bone marrow stem cells in type 2 diabetes.
TLDR
Regulation of miR-491-5p expression could improve osteogenic differentiation of jawbone mesenchymal stem cells in patients with type 2 diabetes.
Potential biomarkers of abnormal osseointegration of implants in type II diabetes mellitus
TLDR
Light is shed on the possible molecular mechanism of abnormal osseointegration caused by bone metabolism disorder in T2DM through bioinformatic analysis of published RNA sequencing data.

References

SHOWING 1-10 OF 56 REFERENCES
New global analysis of the microRNA transcriptome of primary tumors and lymph node metastases of papillary thyroid cancer
TLDR
The results showed that down-regulated microRNAs can be used as new potential common biomarkers of P TC and to distinguish main subtypes of PTC.
Integrated Analysis of Thyroid Cancer Public Datasets Reveals Role of Post-Transcriptional Regulation on Tumor Progression by Targeting of Immune System Mediators
TLDR
Light is shed on the post-transcriptional regulation of gene expression in differentiated and undifferentiated thyroid cancers, revealing a potential role of miRNAs in modulation of tumor-host interaction molecules, particularly ECM molecules and immune system mediators, which could stimulate crosstalk between tumors and the immune system to generate a more aggressive behavior.
Intratumor heterogeneity and clonal evolution in an aggressive papillary thyroid cancer and matched metastases.
TLDR
The first, to the authors' knowledge, deep sequencing study comparing the mutational spectra in a PTC and both LN and distant metastases is presented, and novel findings concerning intra-tumor heterogeneity, clonal evolution and metastases dissemination in thyroid cancer are yielded.
CXCR4 expression correlates with the degree of tumor infiltration and BRAF status in papillary thyroid carcinomas
TLDR
The data indicate that CXCR4 expression and BRAF mutation status could cooperatively induce and promote a more aggressive phenotype in papillary thyroid carcinoma through several pathways and specifically increase the tumors’ spread outside of the thyroid gland.
Standard and emerging therapies for metastatic differentiated thyroid cancer.
TLDR
Both traditional and novel treatments for metastatic differentiated thyroid cancer are discussed with a particular focus on emerging treatments for patients with radioactive iodine-refractory disease.
A 5-MicroRNA Signature for Lung Squamous Cell Carcinoma Diagnosis and hsa-miR-31 for Prognosis
TLDR
A new diagnostic microRNA classifier for SCC among Chinese patients and a new prognostic biomarker, hsa-miR-31 are identified.
Programmed death-ligand 1 overexpression is a prognostic marker for aggressive papillary thyroid cancer and its variants
TLDR
PD-L1 positive expression in PTC correlates with a greater risk of recurrence and shortened disease free survival supporting its potential application as a prognostic marker for PTC.
Identification of potential therapeutic targets for papillary thyroid carcinoma by bioinformatics analysis
TLDR
S100A6, MET and CDKN1C may exhibit key roles in the progression and development of P TC, and may be used as specific therapeutic targets in the treatment of PTC, however, further experiments are required to confirm these results.
miR-486-5p suppresses prostate cancer metastasis by targeting Snail and regulating epithelial–mesenchymal transition
TLDR
Findings suggest that miR-486-5p plays a suppressive role in mediating the migration and invasion of PCa by directly suppressing the protein expression of Snail and may provide a potential therapeutic target for the disease.
...
...