MicroRNA‑143 targets CD44 to inhibit breast cancer progression and stem cell-like properties.

@article{Yang2016MicroRNA143TC,
  title={MicroRNA‑143 targets CD44 to inhibit breast cancer progression and stem cell-like properties.},
  author={ZhuangQing Yang and Dedian Chen and Jianyun Nie and Shaoqiang Zhou and Jiankui Wang and Qi Tang and Xiaojuan Yang},
  journal={Molecular medicine reports},
  year={2016},
  volume={13 6},
  pages={
          5193-9
        }
}
CD44 is closely linked to breast cancer progression; however, the regulatory functions of microRNAs (miRs) in breast cancer have yet to be fully elucidated. In order to investigate the regulation of CD44 by miRs in breast cancer, the present study isolated CD44+ and CD44- breast cancer cells by flow cytometry, revealing that CD44+ cells were enriched in transplanted compared with those in primary breast cancers, and that their proliferation and stem-cell sphere formation ability were enhanced… 
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Characterizing CD44 regulatory microRNAs as putative therapeutic agents in human melanoma
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Using a novel method for miR affinity purification miR-143-3p was identified as most potent binder to the 3’ untranslated region (UTR) of CD44, which affects growth characteristics of melanoma cells suggesting the implementation of miR+3p as as a potential anti-CD44 therapy of malignant melanoma.
MicroRNA‑3666 inhibits breast cancer cell proliferation by targeting sirtuin 7.
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It is indicated that miR‑3666 suppresses breast cancer cell proliferation by targeting SIRT7, and is proposed as a potential candidate for breast cancer therapy.
miR-143-3p targeting LIM domain kinase 1 suppresses the progression of triple-negative breast cancer cells.
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Data demonstrated that miR-143-3p functioned as a suppressor gene in TNBC and that mi R-143 targeted therapy may be a new strategy for TNBC treatment.
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MicroRNA-143 functions as a tumor suppressor in neuroblastoma by targeting bone morphogenetic protein-7
TLDR
It is demonstrated for the first time that miR-143 functions as a tumor suppressor in NB by directly targeting BMP7, and is suggested as a potential thera peutic target for NB patients in the future.
CD44 as a tumor biomarker and therapeutic target
TLDR
The pleiotropic roles of CD44 in carcinoma potentially offering new molecular target for therapeutic intervention, as well as the potential CD44-targeting therapy for cancer management are outlined.
The biology and role of CD44 in cancer progression: therapeutic implications
TLDR
Current data on the structural and functional properties of CD44, the known roles for CD44 in tumorigencity, the regulation ofCD44 expression, and the potential for targeting CD44 for cancer therapy are reviewed.
EGCG inhibits CSC‐like properties through targeting miR‐485/CD44 axis in A549‐cisplatin resistant cells
TLDR
It was found that CSC‐like phenotypes were much more enriched in A549/cisplatin (A549/CDDP) cells compared to A549‐parental cells and it was implied that stemness features and CSC population were suppressed by EGCG‐modulated miR‐485/CD44 axis in A548/ CDDP cells.
Insulin-like growth factor-I induces chemoresistence to docetaxel by inhibiting miR-143 in human prostate cancer
TLDR
It is shown that IGF-I induces docetaxel resistance and upregulates IGF-IR and IRS1 expression through miR-143 downregulation, whereas miR -143 acts as a tumor suppressor by targeting its targets IGF- IR and IRS 1.
CD44: A Multifunctional Mediator of Cancer Progression
TLDR
There are contradictory results regarding whether high or low CD44 expression is associated with worsening clinicopathological features, such as a higher tumour histological grade, advanced tumour stage and poorer survival rates, but nonetheless, high CD 44 expression significantly contributes to enhanced tumourigenic mechanisms; hence, CD44 is an important clinical target.
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