MicroPET imaging of brain tumor angiogenesis with 18F-labeled PEGylated RGD peptide

@article{Chen2003MicroPETIO,
  title={MicroPET imaging of brain tumor angiogenesis with 18F-labeled PEGylated RGD peptide},
  author={Xiaoyuan Chen and Ryan Park and Yingping Hou and Vazgen Khankaldyyan and Ignacio Gonzales-Gomez and Michel Tohme and James R. Bading and Walter E. Laug and Peter S. Conti},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2003},
  volume={31},
  pages={1081-1089}
}
We have previously labeled cyclic RGD peptide c(RGDyK) with fluorine-18 through conjugation labeling via a prosthetic 4-[18F]fluorobenzoyl moiety and applied this [18F]FB-RGD radiotracer for αv-integrin expression imaging in different preclinical tumor models with good tumor-to-background contrast. However, the unfavorable hepatobiliary excretion and rapid tumor washout rate of this tracer limit its potential clinical applications. The aims of this study were to modify the [18F]FB-RGD tracer by… CONTINUE READING
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