MicroPET and autoradiographic imaging of breast cancer alpha v-integrin expression using 18F- and 64Cu-labeled RGD peptide.

@article{Chen2004MicroPETAA,
  title={MicroPET and autoradiographic imaging of breast cancer alpha v-integrin expression using 18F- and 64Cu-labeled RGD peptide.},
  author={Xiaoyuan Chen and Ryan Park and Michel Tohme and Anthony H Shahinian and James R. Bading and Peter S. Conti},
  journal={Bioconjugate chemistry},
  year={2004},
  volume={15 1},
  pages={41-9}
}
Cell adhesion molecules alphavbeta3 and alphavbeta5 play a pivotal role in tumor angiogenesis and metastasis. Antiangiogenic therapy by using small peptide antagonists of alphav-integrins slows tumor growth and prevents tumor spread. The ability to visualize and quantify integrin expression will enable selection of appropriate patients for clinical trials, following determination of treatment efficacy and development of new potent drugs. We have previously labeled cyclic RGD peptide c(RGDyK… CONTINUE READING