MicroPET/CT imaging of αvβ3 integrin via a novel 68Ga-NOTA-RGD peptidomimetic conjugate in rat myocardial infarction

@article{Menichetti2013MicroPETCTIO,
  title={MicroPET/CT imaging of αvβ3 integrin via a novel 68Ga-NOTA-RGD peptidomimetic conjugate in rat myocardial infarction},
  author={Luca Menichetti and Claudia Kusmic and Daniele Panetta and Daniela Arosio and Debora Petroni and Marco Matteucci and Piero Antonio Salvadori and Cesare Casagrande and Antonio L’Abbate and Leonardo Manzoni},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2013},
  volume={40},
  pages={1265-1274}
}
The αvβ3 integrin is expressed in angiogenic vessels and is a potential target for molecular imaging of evolving pathological processes. Its expression is upregulated in cancer lesions and metastases as well as in acute myocardial infarction (MI) as part of the infarct healing process. The purpose of our study was to determine the feasibility of a new imaging approach with a novel 68Ga-2,2′,2″-(1,4,7-triazonane-1,4,7-triyl)triacetic acid (NOTA)-arginine-glycine-aspartic acid (RGD) construct to… CONTINUE READING

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