Micro1-opioid antagonist naloxonazine alters ethanol discrimination and consumption.

  title={Micro1-opioid antagonist naloxonazine alters ethanol discrimination and consumption.},
  author={Molina Mhatre and Frank Holloway},
  volume={29 2},
The endogenous opioid system is implicated in excessive ethanol-drinking behavior. However, the role of individual opioid receptor subtypes in the mechanism underlying excessive ethanol-drinking behavior is not yet well understood. Therefore, we investigated the ability of a selective micro1-opioid antagonist, naloxonazine, to modulate ethanol-drinking behavior and ethanol discrimination in a rat model with the use of ethanol self-administration and drug discrimination paradigms. The effects of… CONTINUE READING


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