Micro-rewiring as a substrate for learning.

  title={Micro-rewiring as a substrate for learning.},
  author={William M Debello},
  journal={Trends in neurosciences},
  volume={31 11},
How does the brain encode life experiences? Recent results derived from vital imaging, computational modeling, cellular physiology and systems neuroscience have pointed to local changes in synaptic connectivity as a powerful substrate, here termed micro-rewiring. To examine this hypothesis, I first review findings on micro-structural dynamics with focus on the extension and retraction of dendritic spines. Although these observations demonstrate a biological mechanism, they do not inform us of… CONTINUE READING