Micro-optical sectioning tomography to obtain a high-resolution atlas of the mouse brain.

@article{Li2010MicroopticalST,
  title={Micro-optical sectioning tomography to obtain a high-resolution atlas of the mouse brain.},
  author={Anan Li and Hui Gong and Bin Zhang and Qingdi Wang and Cheng Yan and Jingpeng Wu and Qian Liu and Shaoqun Zeng and Qingming Luo},
  journal={Science},
  year={2010},
  volume={330 6009},
  pages={1404-8}
}
The neuroanatomical architecture is considered to be the basis for understanding brain function and dysfunction. However, existing imaging tools have limitations for brainwide mapping of neural circuits at a mesoscale level. We developed a micro-optical sectioning tomography (MOST) system that can provide micrometer-scale tomography of a centimeter-sized whole mouse brain. Using MOST, we obtained a three-dimensional structural data set of a Golgi-stained whole mouse brain at the neurite level… CONTINUE READING
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