Micro-Structural Brain Alterations in Aviremic HIV+ Patients with Minor Neurocognitive Disorders: A Multi-Contrast Study at High Field

@inproceedings{Granziera2013MicroStructuralBA,
  title={Micro-Structural Brain Alterations in Aviremic HIV+ Patients with Minor Neurocognitive Disorders: A Multi-Contrast Study at High Field},
  author={Cristina Granziera and Alessandro Daducci and Samanta Simioni and Matthias Cavassini and Alexis Roche and Djalel Eddine Meskaldji and Tobias Kober and M{\'e}lanie M{\'e}tral and Alexandra Calmy and Gunther Helms and Bernard Hirschel and François Lazeyras and Reto Meuli and Gunnar Krueger and Renaud A. Du Pasquier},
  booktitle={PloS one},
  year={2013}
}
OBJECTIVE Mild neurocognitive disorders (MND) affect a subset of HIV+ patients under effective combination antiretroviral therapy (cART). In this study, we used an innovative multi-contrast magnetic resonance imaging (MRI) approach at high-field to assess the presence of micro-structural brain alterations in MND+ patients. METHODS We enrolled 17 MND+ and 19 MND- patients with undetectable HIV-1 RNA and 19 healthy controls (HC). MRI acquisitions at 3T included: MP2RAGE for T1 relaxation times… CONTINUE READING