Micro-RNA-like effects of complete intronic sequences.

  title={Micro-RNA-like effects of complete intronic sequences.},
  author={Aubrey E. Hill and Jeong Soo Hong and Hui Wen and Lihong Teng and David T McPherson and Sylvia A. McPherson and Dana N. Levasseur and Eric Sorscher},
  journal={Frontiers in bioscience : a journal and virtual library},
MicroRNAs (miRNAs) have been suggested as suppressors of numerous target genes in human cells. In this report, we present gene chip array data indicating that in the absence of miRNA sequences, complete human introns are similarly capable of coordinating expression of large numbers of gene products at spatially diverse sites within the genome. The expression of selected intronic sequences (6a, 14b and 23) derived from the cystic fibrosis transmembrane conductance regulator (CFTR) gene caused… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 14 extracted citations


Publications referenced by this paper.
Showing 1-10 of 44 references

Accelerating networks in biology, engineering, and society

  • Mattick J.S., J. Gagen
  • Science 307, 856-8
  • 2005
3 Excerpts

What makes a human

  • J. S. Mattick
  • The Scientist 19(4),
  • 2005
3 Excerpts

reveals frequent coexperssion with neighbouring miRNAs and host genes

  • Y. Aloni, R. Dhar, O. Laub, M. Horowitz, G. Khoury
  • 2005

& E . Sorscher : Common structural patterns in human genes

  • K Yoshimura
  • Bioinformatics
  • 2004

Similar Papers

Loading similar papers…