Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity.

@article{GueraudeArellano2011MicroRNADI,
  title={Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity.},
  author={Mireia Guerau-de-Arellano and Kristen M. Smith and Jakub Godlewski and Y Liu and Ryan C Winger and Sean E Lawler and Caroline C. Whitacre and Michael Karl Racke and Amy E. Lovett-Racke},
  journal={Brain : a journal of neurology},
  year={2011},
  volume={134 Pt 12},
  pages={3578-89}
}
Pro-inflammatory T cells mediate autoimmune demyelination in multiple sclerosis. However, the factors driving their development and multiple sclerosis susceptibility are incompletely understood. We investigated how micro-RNAs, newly described as post-transcriptional regulators of gene expression, contribute to pathogenic T-cell differentiation in multiple sclerosis. miR-128 and miR-27b were increased in naïve and miR-340 in memory CD4(+) T cells from patients with multiple sclerosis, inhibiting… CONTINUE READING