Micro-LED arrays: a tool for two-dimensional neuron stimulation
@article{Poher2008MicroLEDAA, title={Micro-LED arrays: a tool for two-dimensional neuron stimulation}, author={Vincent Poher and Nir Grossman and G T Kennedy and Konstantin Nikolic and H. X. Zhang and Zheng Gong and Emmanuel M. Drakakis and Erdan Gu and Martin D. Dawson and Paul M.W. French and Patrick Degenaar and Mark A A Neil}, journal={Journal of Physics D: Applied Physics}, year={2008}, volume={41}, pages={094014} }
Stimulating neuron cells with light is an exciting new technology that is revolutionizing the neurosciences. To date, due to the optical complexity that is involved, photostimulation has only been achieved at a single site using high power light sources. Here we present a GaN based micro-light emitting diode (LED) array that can open the way to multi-site photostimulation of neuron cells. The device is a two-dimensional array of micrometre size LED emitters. Each emitter has the required…
111 Citations
A New Individually Addressable Micro-LED Array for Photogenetic Neural Stimulation
- BiologyIEEE Transactions on Biomedical Circuits and Systems
- 2010
The results show that the emitters have sufficient radiance at the required wavelength to stimulate neurons expressing channelrhodopsin-2 (ChR2) and the system optically integrated into a microscope environment and patch clamp electrophysiology.
Multi-site optical excitation using ChR2 and micro-LED array.
- BiologyJournal of neural engineering
- 2010
A simple and powerful solution based on an array of high-power micro light-emitting diodes (micro-LEDs) that can generate arbitrary optical excitation patterns on a neuronal sample with micrometre and millisecond resolution is presented.
Individually addressable optoelectronic arrays for optogenetic neural stimulation
- Biology2010 Biomedical Circuits and Systems Conference (BioCAS)
- 2010
The results show that the emitters have sufficient radiance at the required wavelength to stimulate neurons expressing channelrhodopsin-2 (ChR2) and an active matrix control address system to allow simultaneous control of 256 individual micro light emitting diodes is described.
Single-Cell Optogenetic Control of Calcium Signaling with a High-Density Micro-LED Array
- BiologyiScience
- 2019
An optogenetic neural stimulation platform for concurrent induction and recording of neural activity
- Biology, Computer ScienceBiOS
- 2010
The Optogenetic Neural Stimulation (ONS) platform is presented which enables complex in-vitro or ex-vivo investigation of neural activity, based on micro-meter sized Light Emitting Diodes integrated onto a single Gallium Nitrite chip.
A 1024-channel 6 mW/mm2 optical stimulator for in-vitro neuroscience experiments
- Physics2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
- 2014
An optical stimulator based on high power LEDs that has 1024 channels and can produce flexible stimulation patterns in each frame, refreshed at above 20 Hz is presented.
Biphasic micro-LED driver for optogenetics
- Biology2016 IEEE Biomedical Circuits and Systems Conference (BioCAS)
- 2016
A biphasic LED driving method to balance the charge over the brain tissue by sending bidirectional pulses and providing different modes of operation for micro-LEDs using the designed H-tree driver circuit is proposed.
Processes for design, construction and utilisation of arrays of light-emitting diodes and light-emitting diode-coupled optical fibres for multi-site brain light delivery.
- Physics, BiologyJournal of engineering
- 2015
The process flow for making LED arrays and LED-coupled optical fiber arrays is described, explaining key optical, electrical, thermal, and mechanical design principles to enable the manufacturing, assembly, and testing of such multi-site targetable optical devices.
A CMOS-based on-chip neural interface device equipped with integrated LED array for optogenetics
- Engineering2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society
- 2012
A novel CMOS-based neural interface device equipped with an integrated micro light source array that has advantages such as simultaneous multi-site stimulation and on-chip optical imaging, that are not available with previously reported LED array device for optogenetics.
GaN-based micro-LED arrays on flexible substrates for optical cochlear implants
- Materials Science
- 2014
Currently available cochlear implants are based on electrical stimulation of the spiral ganglion neurons. Optical stimulation with arrays of micro-sized light-emitting diodes (µLEDs) promises to…
References
SHOWING 1-10 OF 35 REFERENCES
Flash photolysis using a light emitting diode: an efficient, compact, and affordable solution.
- BiologyCell calcium
- 2005
Rapid neurotransmitter uncaging in spatially defined patterns
- BiologyNature Methods
- 2005
A new optical system for rapid uncaging in arbitrary patterns to emulate complex neural activity using TeO2 acousto-optical deflectors to steer an ultraviolet beam rapidly and can uncage at over 20,000 locations per second.
Efficient flip-chip InGaN micro-pixellated light-emitting diode arrays: promising candidates for micro-displays and colour conversion
- Engineering
- 2008
Flip-chip InGaN micro-pixellated LED arrays with high pixel density and improved device performance are presented. The devices, with 64 × 64 elements, each of which have a 20 µm emission aperture on…
Light-activated ion channels for remote control of neuronal firing
- Biology, ChemistryNature Neuroscience
- 2004
These synthetic photoisomerizable azobenzene-regulated K+ (SPARK) channels allow rapid, precise and reversible control over neuronal firing, with potential applications for dissecting neural circuits and controlling activity downstream from sites of neural damage or degeneration.
Microstripe-array InGaN light-emitting diodes with individually addressable elements
- PhysicsIEEE Photonics Technology Letters
- 2006
High-performance InGaN light-emitting diodes consisting of 120 side-by-side and individually addressable microstripe elements have been successfully fabricated. Each stripe in these devices is 24 mum…
Modeling and Engineering aspects of ChannelRhodopsin2 System for Neural Photostimulation
- Biology2006 International Conference of the IEEE Engineering in Medicine and Biology Society
- 2006
A mathematical model for the photocycle of this protein, Channelrhodopsin-2, is developed, which gives results which are in good agreement with experimental measurements and engineering aspects of using this ChR2 system as a phototransduction mechanism are examined.
Kinetic evaluation of photosensitivity in genetically engineered neurons expressing green algae light-gated channels
- BiologyNeuroscience Research
- 2006
Multimodal fast optical interrogation of neural circuitry
- BiologyNature
- 2007
An archaeal light-driven chloride pump from Natronomonas pharaonis is identified and developed for temporally precise optical inhibition of neural activity and forms a complete system for multimodal, high-speed, genetically targeted, all-optical interrogation of living neural circuits.
Long term recordings with microelectrode arrays: Studies of transcription-dependent neuronal plasticity and axonal regeneration
- BiologyJournal of Physiology-Paris
- 2006
Confocal microscopic imaging of fast UV-laser photolysis of caged compounds
- Biology, ChemistryJournal of Neuroscience Methods
- 2004