Micro-CT evaluation of tooth, calvaria and mechanical stress-induced tooth movement in adult Runx2/Cbfa1 heterozygous knock-out mice.

Abstract

Runx2/Cbfa1 is essential for osteoblast differentiation and bone formation. Runx2 null mice (Runx2(-/-)) completely lack mineralized tissue and die soon after birth, whereas Runx2 heterozygous knock-out mice (Runx2(+/-)) stay alive but show morphological defects in the skeletal system as observed in cleidocranial dysplasia (CCD) in humans. The aim of this… (More)

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