Micro/kappa opioid interactions in rhesus monkeys: implications for analgesia and abuse liability.

@article{Negus2008MicrokappaOI,
  title={Micro/kappa opioid interactions in rhesus monkeys: implications for analgesia and abuse liability.},
  author={S. Stevens Negus and Katrina M Schrode and Glenn W. Stevenson},
  journal={Experimental and clinical psychopharmacology},
  year={2008},
  volume={16 5},
  pages={386-99}
}
Micro opioid receptor agonists are clinically valuable as analgesics; however, their use is limited by high abuse liability. Kappa opioid agonists also produce antinociception, but they do not produce micro agonist-like abuse-related effects, suggesting that they may enhance the antinociceptive effects and/or attenuate the abuse-related effects of micro agonists. To evaluate this hypothesis, the present study examined interactions between the micro agonist fentanyl and the kappa agonist U69,593… CONTINUE READING
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