Miconazole oral gel enhances acenocoumarol anticoagulant activity: a report of three cases.

@article{Ortin1999MiconazoleOG,
  title={Miconazole oral gel enhances acenocoumarol anticoagulant activity: a report of three cases.},
  author={Miguel Ortin and J I Olalla and Mar{\'i}a Jos{\'e} Muruzabal and Felipe Peralta and Mauricio A. Gutierrez},
  journal={The Annals of pharmacotherapy},
  year={1999},
  volume={33 2},
  pages={175-7}
}
OBJECTIVE To describe three cases of interaction between miconazole oral gel and acenocoumarol, manifested as an increase in the international normalized ratio (INR). CASE SUMMARIES Three patients (62-year-old woman, 89-year-old woman, 43-year-old man) following oral antithrombotic treatment with acenocoumarol for different pathologies were diagnosed with oral candidiasis and started miconazole oral gel. In all cases, the previous INR values were repeatedly within the therapeutic range. The… CONTINUE READING