Miconazole: A Review of its Antifungal Activity and Therapeutic Efficacy

@article{Sawyer2012MiconazoleAR,
  title={Miconazole: A Review of its Antifungal Activity and Therapeutic Efficacy},
  author={Phyllis R. Sawyer and Rex N. Brogden and Roger Martin Pinder and Trevor M. Speight and Graeme S. Avery},
  journal={Drugs},
  year={2012},
  volume={9},
  pages={406-423}
}
SummaryMiconazole2, a synthetic imidazole derivative, is a new topical antifungal agent for use in the local treatment of vaginal, and skin and nail infections due to yeasts and dermatophytes. It is particularly active against Candida spp., Trichophyton spp., Epidermophyton spp., Microsporum spp. and Pityrosporon orbiculare (Malassezia furfur), but also possesses some activity against Gram-positive bacteria.In vaginal candidiasis, miconazole vaginal cream has produced higher cure rates than… 
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96 Citations
Highly Influential Citations
2
Background Citations
13
Methods Citations
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Results Citations
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96 Citations

Miconazole: A Preliminary Review of its Therapeutic Efficacy in Systemic Fungal Infections

In in vivo studies, intramuscular miconazole markedly increased the survival rate of rats with experimental systemic candidosis compared with placebo controls, and increased survival of mice infected with Coccidioides immitis, however, subcutaneous and intraperitoneal administration were ineffective in treating miceinfected with Cryptococcus neoformans.

Antifungal Agents Used in Systemic Mycoses

With the imidazoles, the authors have entered a new era of antifungal therapy which may produce even better antIFungal agents than those currently available, and two members, miconazole and ketoconazole, are promising agents.

Treatment and Prophylaxis of Tinea Infections

The modern formulations fully meet the requirements of being well tolerated, involving little risk and acting specifically against relevant pathogens, however, the response rates to date do not always come up to the high expectations offered by in vitro studies.

Miconazole, a pharmacological barrier to skin fungal infections

Miconazole is characterized by high safety, efficacy and versatility, and a unique, multifaceted nature of activity in the treatment of dermatomycoses, and exhibits a fungicidal effect against a number of fungal species, due to hydrogen peroxide accumulation.

New insights on the antibacterial efficacy of miconazole in vitro

Topically applied miconazole might be a therapeutic option in skin infections especially caused by gram‐positive bacteria even by those strains which are resistant to antibiotics.

NOVEL CARRIERS IN TOPICAL ANTIFUNGAL THERAPY OF MICONAZOLE

This review article focuses on the new alternative formulation approaches to improve skin penetration of antifungal drugs miconazole.

Mucoadhesive Potential of Whey Protein Concentrate in Miconazole Mucoadhesive Prolong Release Tablets

The optimized combination of WPC/HPMC/Lactose through a statistical study showed signi icant bioadhesion to the porcine mucosa and prolong drug release for 10hrs.

Ketoconazole, an oral antifungal: laboratory and clinical assessment of imidazole drugs.

Initial clinical evaluation has produced responses to therapy with 200-400 mg/day in 13 of 16 evaluable patients with systemic and superficial fungal infections, involving 10 fungal pathogens.

Antifungal Therapy in Eye Infections: New Drugs, New Trends

This chapter presents information about the major antifungal drugs used in eye infections, their dosages, administration routes, side effects and overall effectiveness.

Efficacy and safety of extemporaneously prepared miconazole eye drops in Candida albicans-induced keratomycosis

The extemporaneously prepared miconazole eye drops are effective and safe to use in keratomycosis and no visible signs of ocular toxicity on instilling it into healthy eyes of rabbits.
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