Miconazole: A Review of its Antifungal Activity and Therapeutic Efficacy

  title={Miconazole: A Review of its Antifungal Activity and Therapeutic Efficacy},
  author={Phyllis R. Sawyer and Rex N. Brogden and Roger Martin Pinder and Trevor M. Speight and Graeme S. Avery},
SummaryMiconazole2, a synthetic imidazole derivative, is a new topical antifungal agent for use in the local treatment of vaginal, and skin and nail infections due to yeasts and dermatophytes. It is particularly active against Candida spp., Trichophyton spp., Epidermophyton spp., Microsporum spp. and Pityrosporon orbiculare (Malassezia furfur), but also possesses some activity against Gram-positive bacteria.In vaginal candidiasis, miconazole vaginal cream has produced higher cure rates than… 

Miconazole: A Preliminary Review of its Therapeutic Efficacy in Systemic Fungal Infections

In in vivo studies, intramuscular miconazole markedly increased the survival rate of rats with experimental systemic candidosis compared with placebo controls, and increased survival of mice infected with Coccidioides immitis, however, subcutaneous and intraperitoneal administration were ineffective in treating miceinfected with Cryptococcus neoformans.

Antifungal Agents Used in Systemic Mycoses

With the imidazoles, the authors have entered a new era of antifungal therapy which may produce even better antIFungal agents than those currently available, and two members, miconazole and ketoconazole, are promising agents.

Treatment and Prophylaxis of Tinea Infections

The modern formulations fully meet the requirements of being well tolerated, involving little risk and acting specifically against relevant pathogens, however, the response rates to date do not always come up to the high expectations offered by in vitro studies.

Miconazole, a pharmacological barrier to skin fungal infections

Miconazole is characterized by high safety, efficacy and versatility, and a unique, multifaceted nature of activity in the treatment of dermatomycoses, and exhibits a fungicidal effect against a number of fungal species, due to hydrogen peroxide accumulation.

New insights on the antibacterial efficacy of miconazole in vitro

Topically applied miconazole might be a therapeutic option in skin infections especially caused by gram‐positive bacteria even by those strains which are resistant to antibiotics.


This review article focuses on the new alternative formulation approaches to improve skin penetration of antifungal drugs miconazole.

Mucoadhesive Potential of Whey Protein Concentrate in Miconazole Mucoadhesive Prolong Release Tablets

The optimized combination of WPC/HPMC/Lactose through a statistical study showed signi icant bioadhesion to the porcine mucosa and prolong drug release for 10hrs.

Ketoconazole, an oral antifungal: laboratory and clinical assessment of imidazole drugs.

Initial clinical evaluation has produced responses to therapy with 200-400 mg/day in 13 of 16 evaluable patients with systemic and superficial fungal infections, involving 10 fungal pathogens.

Antifungal Therapy in Eye Infections: New Drugs, New Trends

This chapter presents information about the major antifungal drugs used in eye infections, their dosages, administration routes, side effects and overall effectiveness.

Efficacy and safety of extemporaneously prepared miconazole eye drops in Candida albicans-induced keratomycosis

The extemporaneously prepared miconazole eye drops are effective and safe to use in keratomycosis and no visible signs of ocular toxicity on instilling it into healthy eyes of rabbits.



Topical Pharmacology of Imidazole Antifungals

  • R. Holt
  • Biology, Medicine
    Journal of cutaneous pathology
  • 1976
The relative value of these topical agents is discussed, and it is suggested that in severe and extensive dermatomycoses consideration should be given to the systemic use of miconazole in support of topical therapy.

Recent developments in antimycotic chemotherapy

It is suggested that at present 5 FC is the drug of choice for candidosis and cryptococcosis, providing careful laboratory monitoring is maintained, while clotrimazole or miconazole is preferable in the therapy of lung aspergilloses.

Miconazole, a New Broad‐spectrum Antimycotic, in the Treatment of Vaginal Candidosis

The first trial of the new compound, miconazole, against vaginal candidosis is reported, with results that indicate it is effective against gram-negative bacteria and not absorbed when administered topically or iiitravaginally.

Clinical studies on clotrimazole as antifungal therapy in obstetrics and gynaecology.

An antifungal potency for the vaginal tablets (100 mg.) comparable with that of other antIFungal vaginal tablets, as determined in vitro, is indicated.

In Vitro Antifungal Activity of Clotrimazole (Bay b 5097)

  • Smith Shadomy
  • Biology, Medicine
    Infection and immunity
  • 1971
The in vitro antifungal activity of clotrimazole was compared with those of amphotericin B, griseofulvin, nystatin, and pyrrolnitrin, and the size of inoculum was shown to have a significant effect on the results of in vitro susceptibility testing with clotrimzole.

Laboratory assessment of the antimycotic drug clotrimazole

Cl clotrimazole may be the first of a long series of imidazole derivatives with varying pharmacological and therapeutic properties, and the significance of low levels of the drug in body fluids, even after prolonged therapy, is discussed.

Chemotherapeutic evaluation of clotrimazole (Bay b 5097, 1 (o-chloro- - -diphenylbenzyl) imidazole).

In vitro, but not in vivo, some gram-positive and gram-negative bacteria are inhibited by low concentrations of clotrimazole, and Pretreatment with the agent may decrease its efficacy because of drug inactivation.

Topical Treatment of Dermatomycoses with Canesten® * ) Cream, a New Antimycotic Compound

Since 1958 topical application could be combined with oral medication of griseofulvin and better results were therefore obtained especially in the treatment of tinea capitis, favus and tinea due to T .

Bilogical and toxicological properties of econazole, a broad-spectrum antimycotic.

Toxicity and teratogenicity studies in different laboratory animals indicate that econazole is well tolerated.

Tioconazole in the Treatment of Vaginal Candidosis

A 3‐day treatment with tioconazole vaginal tablets (Gyno‐Trosid; Pfizer) was used in 30 patients with vaginal candidosis during a prospective, mycologically controlled study and there was a 100% cure rate on microscopic and mycological examination.