Michaelis-Menten kinetics of stiripentol in normal humans.

  title={Michaelis-Menten kinetics of stiripentol in normal humans.},
  author={Ren{\'e} H. Levy and Pierre Loiseau and Michel Guyot and Henri Bl{\'e}haut and Jordi Tor and Terry Moreland},
  volume={25 4},
Michaelis-Menten kinetic parameters for stiripentol, and anticonvulsant, were assessed in six normal volunteers. Stiripentol was administered orally three times a day in dosage increments of 600, 1,200, and 1,800 mg/day for consecutive periods of 3, 4, and 7 days, respectively. Stiripentol steady-state levels at the three dosing rates increased more than proportionally with dose. The mean +/- SD oral clearance of stiripentol at 600 mg/day (1,090 +/- 624 L/day) was significantly greater (p less… CONTINUE READING

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