Michael acceptor in gambogic acid--Its role and application for potent antitumor agents.

Abstract

Gambogic acid (GA), a natural product with unique structure, was reported to have broad antiproliferation activities against cancer cell lines. As a reactive Michael acceptor, the 10-position of GA is susceptible to nucleophiles, thus limiting its clinical application as an anticancer agent. Moreover, the 6-OH forms an intramolecular hydrogen bond with 8-CO… (More)
DOI: 10.1016/j.bmcl.2015.04.100

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