Micellar formulations for drug delivery based on mixtures of hydrophobic and hydrophilic Pluronic block copolymers.

@article{Oh2004MicellarFF,
  title={Micellar formulations for drug delivery based on mixtures of hydrophobic and hydrophilic Pluronic block copolymers.},
  author={Kyung Taek Oh and Tatiana K. Bronich and Alexander V Kabanov},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2004},
  volume={94 2-3},
  pages={411-22}
}
Micelles formed by Pluronic block copolymers (PBC) have been studied in multiple applications as drug delivery systems. Hydrophobic PBC form lamellar aggregates with a higher solubilization capacity than spherical micelles formed by hydrophilic PBC. However, they also have a larger size and low stability. To overcome these limitations, binary mixtures from hydrophobic PBC (L121, L101, L81, and L61) and hydrophilic PBC (F127, P105, F87, P85, and F68) were prepared. In most cases, PBC mixtures… CONTINUE READING