Micellar Solubilization of Some Poorly Soluble Antidiabetic Drugs: A Technical Note

@article{Seedher2008MicellarSO,
  title={Micellar Solubilization of Some Poorly Soluble Antidiabetic Drugs: A Technical Note},
  author={Neelam Seedher and Mamta Kanojia},
  journal={AAPS PharmSciTech},
  year={2008},
  volume={9},
  pages={431-436}
}
Poor aqueous solubility is usually a major obstacle in the development of therapeutic agents. Some of the approaches commonly used to enhance the solubility of poorly soluble drugs include use of co-solvents (1–2), selection of salt form (3–4), increase of specific surface area by reduction of particle size (5), complex formation with excipients such as hydrophilic polymers and cyclodextrins (6–8), change of crystal form (polymorphism/amorphism) (9) and preparation of solid dispersions (10–11… 

Tables from this paper

Enhancement of solubilization and bioavailability of poorly soluble drugs by physical and chemical modifications : A recent review
The aim of this review was to improve the solubility and bioavailability of poorly soluble drugs by using various approaches like physical, chemical and others modifications or techniques. The
Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules
TLDR
This review will discuss the aspects and role of dendrimers in the solubility enhancement of poorly soluble drugs, and highlight the important and relevant properties of d endrimers which contribute toward drug solubilization.
STUDY ON THE INFLUENCE OF COSOLVENT AND SURFACTANT ON SOLUBILIZATION OF EFAVIRENZ
The very poor aqueous solubility of drugs, give rise to difficulties in the design of pharmaceutical formulations and very often lead to variable oral bioavailability. Cosolvency and micellar
A REVIEW ON EXTRACTION OF HERBAL DRUGS AND THE ENHANCEMENT OF SOLUBILITY BY HYDROTROPY TECHNIQUE
Aqueous solubility of a therapeutically active substance is a key property as it governs dissolution, absorption and thus the therapeutic effects in-vivo. Recently more than 40% APIs (Active
VARIOUS TECHNIQUES ENHANCING BIOAVAILABILTY OF POORLY WATER SOLUBLE DRUGS
TLDR
It is now possible that to increase the solubility of poorly soluble drugs with the help of various techniques such as Physical method, Chemical method, Co-crystallisation, co-solvency solubilizing agents, molecular encapsulation with cyclodextrins,nanotechnology approaches and hydrotropy.
Nanonization techniques to overcome poor water-solubility with drugs
TLDR
How drug nanoparticles and nanocarriers, especially lipid-based nanosystems, can overcome these challenges and which of these approaches are already available on the market is included.
Drug Solubility: Importance and Enhancement Techniques
TLDR
Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include physical and chemical modifications of drug and other methods like particle size reduction, crystal engineering, salt formation, solid dispersion, use of surfactant, complexation, and so forth.
...
...

References

SHOWING 1-10 OF 28 REFERENCES
Micellar solubilization of drugs.
  • C. Rangel-Yagui, A. Pessoa, L. C. Tavares
  • Chemistry, Biology
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
  • 2005
TLDR
The application of micelles in drug delivery, in order to minimize drug degradation and loss, to prevent harmful side effects, and to increase drug bioavailability, is presented.
Micellar solubilization of ibuprofen: influence of surfactant head groups on the extent of solubilization
An important property of micelles with particular significance in pharmacy is their ability to increase the solubility of poorly soluble drugs in water, thus increasing their bioavailability. In this
Combined effect of cosolvent and cyclodextrin on solubilization of nonpolar drugs.
TLDR
A simple mathematical model has been developed to describe the combined effect of cosolvency and complexation on nonpolar drug solubilization that explains the decline in drug Solubility produced by low cosolvent concentrations as well as the increase in the solubilityproduced by high cosolent concentrations that are observed at all cyclodextrin concentrations.
Solubilization of fluasterone.
TLDR
This study investigates and assesses the solubility enhancement of Fluasterone by various techniques including cosolvency, micellization, and complexation, and the modified beta-cyclodextrins were found to be the most effective.
Study of the solubilization of gliclazide by aqueous micellar solutions.
TLDR
It was found that gliclazide solubility increases with increasing the carbon chain length of cationic surfactant micelles and decreases with increases the carbonChain length of anionic surfactants.
Comparative studies on effect of some hydrophilic polymers onthe dissolution rate of a poorlywater soluble drug, meloxicam
In the present investigation, effect of hydrophilic polymers like gum karaya (GK), modified gum karaya (MGK), guar gum (GG), xanthan gum (XG), hydroxypropyl methylcellulose (HPMC) and sodium carboxy
Stability and Solubility of Celecoxib-PVP Amorphous Dispersions: A Molecular Perspective
TLDR
The solubility enhancement and enthalpy relaxation studies with respect to PVP concentration helped in a better prediction of role of carrier and optimization of concentration in the use of solid dispersions or amorphous systems.
Solubilization Of Etodolac For Parenteral Administration
Etodolac (ETO) is a nonsteroidal antiinflammatory drug (NSAID) that exhibits analgesic, antipyretic and antiinflammatory activities and is practically Insoluble in water. The solubility of ETO in
Development and Evaluation of Glyburide Fast Dissolving Tablets Using Solid Dispersion Technique
TLDR
The glyburide dissolution profile from the newly developed tablets was clearly better than those from various commercial tablets at the same drug dosage, with a 135% increase in drug dissolution efficiency at 60 min in comparison with a reference tablet formulation containing the pure micronized drug.
...
...