Micellar Nanocontainers Distribute to Defined Cytoplasmic Organelles
@article{Savic2003MicellarND, title={Micellar Nanocontainers Distribute to Defined Cytoplasmic Organelles}, author={Radoslav Savić and Laibin Luo and Adi Eisenberg and Du{\vs}ica Maysinger}, journal={Science}, year={2003}, volume={300}, pages={615 - 618} }
Block copolymer micelles are water-soluble biocompatible nanocontainers with great potential for delivering hydrophobic drugs. An understanding of their cellular distribution is essential to achieving selective delivery of drugs at the subcellular level. Triple-labeling confocal microscopy in live cells revealed the localization of micelles in several cytoplasmic organelles, including mitochondria, but not in the nucleus. Moreover, micelles change the cellular distribution of and increase the…
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