Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity.

@article{Osswald2005MiceWT,
  title={Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity.},
  author={Christina Osswald and Katharina Baumgarten and Frank T. St{\"u}mpel and Valentin Gorboulev and Marina Akimjanova and Klaus-Peter Knobeloch and Ivan Horak and Reinhart Kluge and Hans-Georg Joost and Hermann Koepsell},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 1},
  pages={78-87}
}
The product of the intronless single copy gene RSC1A1, named RS1, is an intracellular 617-amino-acid protein that is involved in the regulation of the Na(+)-d-glucose cotransporter SGLT1. We generated and characterized RS1 knockout (RS1(-/-) mice. In the small intestines of RS1(-/-) mice, the SGLT1 protein was up-regulated sevenfold compared to that of wild-type mice but was not changed in the kidneys. The up-regulation of SGLT1 was posttranscriptional. Small intestinal d-glucose uptake… CONTINUE READING

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