Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve.

@article{Goddard1996MiceWT,
  title={Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve.},
  author={Judy M. Goddard and Mireille Rossel and Nancy R Manley and Mario R Capecchi},
  journal={Development},
  year={1996},
  volume={122 10},
  pages={3217-28}
}
Mice were generated with targeted disruptions in the hoxb-1 gene. Two separate mutations were created: the first disrupts only the homeodomain and the second inactivates the first exon as well as the homeodomain. The phenotypes associated with these two mutant alleles are indistinguishable in surviving adult mice. The predominant defect in these mutant mice is a failure to form the somatic motor component of the VIIth (facial) nerve, possibly through a failure to specify these neurons. The… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 38 references

The role of Hox genes in hindbrain development

M. R. 232-249. Capecchi
1997
View 1 Excerpt

phosphotransferase gene from transposon

A. M. Boulet, M. R. Capecchi
1996
View 2 Excerpts

Compound mutants

A. Bradley, R. R. Behringer
1995

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