Mice with selective elimination of striatal acetylcholine release are lean, show altered energy homeostasis and changed sleep/wake cycle

@article{Guzman2013MiceWS,
  title={Mice with selective elimination of striatal acetylcholine release are lean, show altered energy homeostasis and changed sleep/wake cycle},
  author={Monica S. Guzman and Xavier De Jaeger and Maria Drangova and Marco A. M. Prado and Robert Gros and Vania F. Prado},
  journal={Journal of Neurochemistry},
  year={2013},
  volume={124}
}
Cholinergic neurons are known to regulate striatal circuits; however, striatal‐dependent physiological outcomes influenced by acetylcholine (ACh) are still poorly under;?>stood. Here, we used vesicular acetylcholine transporter (VAChT)D2‐Cre‐flox/flox mice, in which we selectively ablated the vesicular acetylcholine transporter in the striatum to dissect the specific roles of striatal ACh in metabolic homeostasis. We report that VAChTD2‐Cre‐flox/flox mice are lean at a young age and maintain… 
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Cardiomyocyte‐secreted acetylcholine is required for maintenance of homeostasis in the heart

  • A. RoyWilliam C. Fields M. Prado
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2013
Cardiomyocyte‐derived ACh is required for maintenance of cardiac homeostasis and regulates critical signaling pathways necessary to maintain normal heart activity, and it is proposed that this non‐neuronal source of ACh boosts parasympathetic cholinergic signaling to counterbalance sympathetic activity regulating multiple aspects of heart physiology.

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Investigating the Effect of Vesicular Acetylcholine Transporter Expression on Central and Peripheral Function

The biochemical characteristics of cholinergic neurons following VAChT overexpression were measured and the behaviour phenotype of these animals was evaluated and the effect of lifelong VACh T overexposure on the age-related impairment of hippocampal structure and function was investigated.

Pannexin 1 regulates adipose stromal cell differentiation and fat accumulation

It is concluded that Panx1 plays a key role in adipose stromal cells during the early stages of adipogenic proliferation and differentiation, regulating fat accumulation in vivo.

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