Mice with selective elimination of striatal acetylcholine release are lean, show altered energy homeostasis and changed sleep/wake cycle

@article{Guzman2013MiceWS,
  title={Mice with selective elimination of striatal acetylcholine release are lean, show altered energy homeostasis and changed sleep/wake cycle},
  author={Monica S. Guzman and Xavier De Jaeger and Maria Drangova and Marco A. M. Prado and Robert Gros and Vania F. Prado},
  journal={Journal of Neurochemistry},
  year={2013},
  volume={124}
}
Cholinergic neurons are known to regulate striatal circuits; however, striatal‐dependent physiological outcomes influenced by acetylcholine (ACh) are still poorly under;?>stood. Here, we used vesicular acetylcholine transporter (VAChT)D2‐Cre‐flox/flox mice, in which we selectively ablated the vesicular acetylcholine transporter in the striatum to dissect the specific roles of striatal ACh in metabolic homeostasis. We report that VAChTD2‐Cre‐flox/flox mice are lean at a young age and maintain… Expand
View on Wiley
onlinelibrary.wiley.com
24 Citations
Highly Influential Citations
2
Background Citations
4
Methods Citations
5

24 Citations

Citation Type

Citation Type

Deletion of the vesicular acetylcholine transporter from pedunculopontine/laterodorsal tegmental neurons modifies gait
TLDR
The results suggest that dysfunction of cholinergic neurons from mesopontine nuclei, which is commonly seen in PD, has causal roles in motor functions and prevention of mesopONTine cholinerg failure may help to prevent/improve postural instability and falls in PD patients. Expand
Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating.
TLDR
It is revealed that loss of acetylcholine leads to a dopamine imbalance in striatal compartments, thereby promoting habits and vulnerability to maladaptive eating in mice. Expand
ChAT–ChR2–EYFP Mice Have Enhanced Motor Endurance But Show Deficits in Attention and Several Additional Cognitive Domains
TLDR
The studies demonstrate that ChAT–ChR2–EYFP mice show altered cholinergic tone that fundamentally differentiates them from wild-type mice, and suggest that increased VAChT expression may disrupt critical steps in information processing. Expand
Mice deficient for striatal Vesicular Acetylcholine Transporter (VAChT) display impaired short-term but normal long-term object recognition memory
TLDR
The pattern of results suggests that striatal cholinergic transmission plays a role in the short-term memory for object features, but not spatial location. Expand
Cardiomyocyte‐secreted acetylcholine is required for maintenance of homeostasis in the heart
  • A. Roy, William C. Fields, +5 authors M. Prado
  • Medicine, Biology
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2013
TLDR
Cardiomyocyte‐derived ACh is required for maintenance of cardiac homeostasis and regulates critical signaling pathways necessary to maintain normal heart activity, and it is proposed that this non‐neuronal source of ACh boosts parasympathetic cholinergic signaling to counterbalance sympathetic activity regulating multiple aspects of heart physiology. Expand
Deficiency of Meis1, a transcriptional regulator, in mice and worms: Neurochemical and behavioral characterizations with implications in the restless legs syndrome
TLDR
The data suggest that Meis1 knockout mice have restless legs syndrome‐like motor restlessness and changes in serum ferritin levels, which may be related to dysfunctional dopaminergic and cholinergic systems. Expand
Hyperactivity and attention deficits in mice with decreased levels of stress-inducible phosphoprotein 1 (STIP1)
TLDR
It is concluded that reduced STIP1 levels can contribute to phenotypes related to ASD, however, future experiments are needed to define whether it is decreased chaperone capacity or impaired prion protein signaling that contributes to these phenotypes. Expand
Investigating the Effect of Vesicular Acetylcholine Transporter Expression on Central and Peripheral Function
Cholinergic neurons use the neurotransmitter acetylcholine extensively throughout the central and peripheral nervous systems. During normal and pathological aging (i.e. Alzheimer’s disease)… Expand
Pannexin 1 regulates adipose stromal cell differentiation and fat accumulation
TLDR
It is concluded that Panx1 plays a key role in adipose stromal cells during the early stages of adipogenic proliferation and differentiation, regulating fat accumulation in vivo. Expand
Cholinergic circuits in cognitive flexibility
TLDR
Strong evidence indicates that cholinergic interneurons from the dorsomedial striatum are essential for facilitating the establishment of a new selected strategy; an effect that seems to depend mainly on activation of muscarinic receptors. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 49 REFERENCES
Novel Strains of Mice Deficient for the Vesicular Acetylcholine Transporter: Insights on Transcriptional Regulation and Control of Locomotor Behavior
TLDR
The results suggest that release of ACh in the brain is normally required to “turn down” neuronal circuits controlling locomotion, and that VAChT mutant mice present preserved neuromuscular function but altered brain cholinergic function and are hyperactive. Expand
Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean
TLDR
It is shown that mice deficient in the M3 muscarinic receptor (M3R-/- mice) display a significant decrease in food intake, reduced body weight and peripheral fat deposits, and very low levels of serum leptin and insulin, and there may be a cholinergic pathway that involves M3-receptor-mediated facilitation of food intake at a site downstream of the hypothalamic leptin/melanocortin system and upstream of the MCH system. Expand
Reduced expression of the vesicular acetylcholine transporter causes learning deficits in mice
TLDR
The memory deficit in object recognition memory observed in VAChT mutant mice could be reversed by cholinesterase inhibitors, suggesting that learning deficits caused by reducedVAChT expression can be ameliorated by restoring ACh levels in the synapse. Expand
Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis.
TLDR
It is suggested that MC4Rs expressed by cholinergic neurons regulate energy expenditure and hepatic glucose production and provide further evidence of the dissociation in pathways mediating the effects of melanocortins on energy balance and glucose homeostasis. Expand
Accumbens cholinergic interneurons play a role in the regulation of body weight and metabolism
TLDR
The results suggest that the altered body weight regulation is partly due to the enhanced metabolic responsiveness to stress. Expand
Mice Deficient for the Vesicular Acetylcholine Transporter Are Myasthenic and Have Deficits in Object and Social Recognition
An important step for cholinergic transmission involves the vesicular storage of acetylcholine (ACh), a process mediated by the vesicular acetylcholine transporter (VAChT). In order to understand the… Expand
The Vesicular Acetylcholine Transporter Is Required for Neuromuscular Development and Function
TLDR
The results indicate that VAChT is essential to the normal development of motor neurons and the release of A choline acetyltransferase, which is essential for life. Expand
The Obesity Susceptibility Gene Carboxypeptidase E Links FoxO1 Signaling in Hypothalamic Pro–opiomelanocortin Neurons with Regulation of Food Intake
TLDR
It is shown that Cpe expression is downregulated by diet-induced obesity and that FoxO1 deletion offsets the decrease, protecting against weight gain, and raises the possibility of targeting Cpe to develop weight loss medications. Expand
Striatal muscarinic receptor antagonism reduces 24‐h food intake in association with decreased preproenkephalin gene expression
TLDR
It is hypothesized that cholinergic interneurons assist in translating hypothalamic energy state signals into food‐directed behaviors via their regulation of striatal opioid peptides through their control of enkephalin gene expression. Expand
Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure
TLDR
It is demonstrated thatMC4Rs in the PVH and/or the amygdala control food intake but that MC4Rs elsewhere control energy expenditure, and association of food intake and energy expenditure reveals unexpected divergence in melanocortin pathways controlling energy balance. Expand
...
1
2
3
4
5
...