Mice with selective elimination of striatal acetylcholine release are lean, show altered energy homeostasis and changed sleep/wake cycle

@article{Guzman2013MiceWS,
  title={Mice with selective elimination of striatal acetylcholine release are lean, show altered energy homeostasis and changed sleep/wake cycle},
  author={Monica S. Guzman and Xavier De Jaeger and Maria Drangova and Marco A. M. Prado and Robert Gros and Vania F. Prado},
  journal={Journal of Neurochemistry},
  year={2013},
  volume={124}
}
Cholinergic neurons are known to regulate striatal circuits; however, striatal‐dependent physiological outcomes influenced by acetylcholine (ACh) are still poorly under;?>stood. Here, we used vesicular acetylcholine transporter (VAChT)D2‐Cre‐flox/flox mice, in which we selectively ablated the vesicular acetylcholine transporter in the striatum to dissect the specific roles of striatal ACh in metabolic homeostasis. We report that VAChTD2‐Cre‐flox/flox mice are lean at a young age and maintain… 
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  • A. RoyWilliam C. Fields M. Prado
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2013
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