Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice.

@article{Murphy2014MiceWM,
  title={Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice.},
  author={Andrew J. Murphy and Lynn E. Macdonald and Sean Stevens and Margaret L. Karow and Anthony T Dor{\'e} and Kevin J. Pobursky and Tammy T. Huang and William T. Poueymirou and Lakeisha Esau and Melissa Meola and Warren Mikulka and Pamela Krueger and Jeanette L. Fairhurst and David M. Valenzuela and Nicholas Papadopoulos and George D. Yancopoulos},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 14},
  pages={5153-8}
}
Mice genetically engineered to be humanized for their Ig genes allow for human antibody responses within a mouse background (HumAb mice), providing a valuable platform for the generation of fully human therapeutic antibodies. Unfortunately, existing HumAb mice do not have fully functional immune systems, perhaps because of the manner in which their genetic humanization was carried out. Heretofore, HumAb mice have been generated by disrupting the endogenous mouse Ig genes and simultaneously… CONTINUE READING
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