Mice with liver composed of human hepatocytes as an animal model for drug testing.

@article{Yoshizato2012MiceWL,
  title={Mice with liver composed of human hepatocytes as an animal model for drug testing.},
  author={Katsutoshi Yoshizato and Chise Tateno and Rie Utoh},
  journal={Current drug discovery technologies},
  year={2012},
  volume={9 1},
  pages={63-76}
}
Conventionally, rodents, mostly mice and rats, have been utilized as animal models for studying drug metabolism and toxicity of new medicines. However, there have been two major problems inherent to these models. One is that there are species differences in major enzymes responsible for drug metabolisms and detoxification such as cytochrome P450 between rodents and humans, and the other is that human hepatitis viruses do not infect rodent livers, which hampers studies for anti-hepatitis virus… CONTINUE READING

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