Mice with decreased cerebral dopamine function following a neurotoxic dose of MDMA (3,4-methylenedioxymethamphetamine, "Ecstasy") exhibit increased ethanol consumption and preference.

@article{Izco2007MiceWD,
  title={Mice with decreased cerebral dopamine function following a neurotoxic dose of MDMA (3,4-methylenedioxymethamphetamine, "Ecstasy") exhibit increased ethanol consumption and preference.},
  author={Mar{\'i}a Izco and Ivanny Marchant and Isabel Escobedo and Ines Peraile and Mercedes de la C{\'a}mara Delgado and Alejandro Higuera-Matas and Oscar Ol{\'i}as and Emilio Ambrosio and Esther O'shea and Mar{\'i}a Isabel Colado},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2007},
  volume={322 3},
  pages={1003-12}
}
MDMA (3,4-methylenedioxymethamphetamine, "ecstasy") administration to mice produces relatively selective long-term neurotoxic damage to dopaminergic pathways. There is strong evidence indicating that the dopamine system plays a key role in the rewarding effects of ethanol and modulates ethanol intake. Using a two-bottle free-choice paradigm, we examined the voluntary consumption and preference for ethanol in mice deficient in cerebral dopamine concentration and dopamine transporter density by… CONTINUE READING

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